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Ergothioneine
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Product Overview
Ergothioneine
A Nature-Identical Cellular Antioxidant & Longevity-Linked Bioactive
Ergothioneine
Ergothioneine (EGT) is a naturally occurring sulfur-containing amino acid–derived antioxidant found in mushrooms and certain microorganisms. Unlike conventional antioxidants, EGT is actively transported into cells via the specific transporter OCTN1, enabling targeted intracellular protection where oxidative stress is most damaging.
Because of its extraordinary stability, cellular selectivity, and biological relevance, Ergothioneine has emerged as a next-generation antioxidant for both nutritional longevity formulations and advanced skincare applications.
CAS Number：
497-30-3
Appearance：
White crystalline powder
Origin：
Nature-identical (biotechnology-derived)
Solubility：
Water-soluble
Odor：
Odorless to slightly characteristic
Assay (HPLC)：
≥ 98.0% (typ. 99%+)
Mechanism of Action
Acetyl Zingerone provides antioxidant and skin-protective effects through three synergistic pathways:
Direct scavenging of reactive oxygen species
Quickly capture and neutralize excess reactive oxygen species within cells
Quenching of singlet oxygen and hydroxyl
Targeted clearance of two strong oxidative free radicals
Protection of mitochondrial integrity
Protecting the structural stability of cellular energy factories
Inhibition of lipid peroxidation
Block the oxidative chain reaction of cell membrane lipids
Unlike many
antioxidants, EGT remains redox-stable, preventing oxidative rebound or secondary radical formation.
Ergothioneine (EGT) Key Benefits
Nutritional Supplement Cosmetic/Skincare
Cellular Longevity Support
Ergothioneine accumulates in mitochondria-rich and oxidative-stress-prone tissues, supporting long-term cellular resilience and metabolic health.
Potent & Stable Antioxidant Defense
Maintains antioxidant activity under physiological conditions where vitamin C, polyphenols, or glutathione rapidly degrade.
Mitochondrial Protection
Helps preserve mitochondrial function by limiting oxidative damage, a key factor in aging and chronic stress.
Inflammation Modulation
Supports balanced inflammatory responses by reducing oxidative triggers upstream of cytokine activation.
Scientific Highlight
Afe and Effective Antioxidant: The Biological Mechanism and Potential Clinical
Applications
Shows ergothioneine’s cellular uptake via OCTN1 and intracellular
antioxidant effects.
Discusses antioxidant, anti-inflammatory, anti-aging functions and mechanisms relevant to skin and
systemic health.
Typical Applications
Nutritional / Health Products
- Cellular antioxidant supplements
- Longevity & healthy aging formulas
- Stress-resilience and recovery products
- Mitochondrial support blends
Cosmetic & Skincare Products
- Anti-aging serums & creams
- Urban pollution defense skincare
- Post-procedure recovery products
- Sensitive-skin and barrier-repair lines
- Premium antioxidant ampoules
Recommended Use Level
- Dietary supplements: Formulation-dependent
- Cosmetic products: Typically 0.1 – 1.0%
Positioning Summary
Ergothioneine is not just another antioxidant.It is a biologically prioritized, cell-selective defense molecule, ideal for brands seeking long-term efficacy, scientific credibility, and premium differentiation in both nutritional health and advanced skincare.